The Field Laboratory

School of Life Sciences, University of Dundee

Welcome

    The laboratory was established in 1994 (Imperial College 1994 - 2004, University of Cambridge 2005 - 2013), and is now at the School of Life Sciences, University of Dundee. The website contains information on research, publications and details of studentships and postdoctoral opportunities. Overseas applicants are especially encouraged to consider specific funding options and schemes offered by the University, and to get in touch with us. Dundee is the UK's leading University at 50 years old, best for life sciences impact in the UK and internationally one of the top 200. We are recognised for expertise across a range of disciplines with specific strength in life sciences, fine arts and graphics/comics.

    Our principle research objectives are the discovery, functional characterisation and validation of novel gene products, drug targets and chemical tools towards neglected diseases to provide therapy, deep insights into protist cell biology and to understand eukaryotic evolution at the molecular level.


Our research

    We exploit multidisciplinary methodology, focusing on cellular systems of trypanosomes and other organisms. We are specifically interested in drug sensitivity, immune evasion, protein/lipid sorting, nuclear architecture, gene expression and virulence. Our work also has a strong evolutionary component, with relevance to eukaryogenesis, re-constructing the evolutionary history of intracellular transport pathways and eukaryotic microbial diversity. Explore our site for information about us, PhD opportunities, post-doctoral positions and reprints.

















Recent publications

Evolutionary origins and specialisations of membrane transport. Dacks, J.B., and Field, M.C (2018) Current Opinions in Cell Biology 53 70 - 76

Activation and mechanisms of resistance to phenoxyborole class trypanosides. Zhang, N., Zoltner, M., Ka-Fai Leung, K-F., Scullion, P.,. Hutchinson, S., del Pino, R.C., Vincent, I., Zhang, Y-K., Freund, Y.R., Alley, M.R.K., Jacobs, R.T., Read, K.D., Barrett, M.P., Horn, D., and Field, M.C., (2018) PLoS Pathogens 14 e1006850

The evolution of organellar coat complexes and organisation of the eukaryotic cell. Rout, M.P., and Field, M.C., (2017) Annual Reviews of Biochemistry 86 637 - 657

Lineage-specific proteins essential for endocytosis in trypanosomes. Manna, P.T., Obado, S., Boehm, C., Gadelha, C., Sali, A., Chait, B.T., Rout, M.P., and Field, M.C., (2017) Journal of Cell Science 130 1379 - 1392

Codependence between Trypanosoma nuclear lamina components in nuclear stability and control of gene expression. Maishman, L., Obado, S., Alsford, S., Bart, J.M., Navarro, M., Horn, D., Ratushny, Aitchison, J.D., Chait, B.T., Rout, M.P., and Field, M.C., (2016)  Nucleic Acids Research 44 10554-10570

Ancient eukaryotic origin and evolutionary plasticity of the nuclear lamina. Koreny, L., and Field, M.C., (2016) Genome Biology and Evolution 8 2663 - 2671

Interactome mapping reveals the evolutionary history of the nuclear pore complex. Obado, S., Brillantes, B., Uryu, K., Zhang, W-Z., Ketaren, N.E., Chait, B.T.  Field, M.C., and Rout, M.P. (2016) PLoS Biology 14 e1002365

Modulation of the surface proteome through multiple ubiquitylation pathways in African trypanosomes. Zoltner, M., Leung, K-F., Alsford, S., Horn, D., and Field, M.C., (2015) PLoS Pathogens 11 e1005236

C. Jackson

IKELOS GmbH