The Field Laboratory

School of Life Sciences

University of Dundee

Scotland

Our research

    We exploit multidisciplinary methodology, focusing on cellular systems of trypanosomes. We are specifically interested in drug sensitivity, immune evasion, protein/lipid sorting, nuclear architecture, gene expression and virulence. Our work also has a strong evolutionary component, with relevance to eukaryogenesis, re-constructing the evolutionary history of intracellular transport pathways and eukaryotic microbial diversity. Explore our site for information about us, PhD opportunities, post-doctoral positions and reprints.

© BRS 2018

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News

BBSRC PhD studentship available jointly with Prof Eric Schirmer at University of Edinburgh on lamina structures. Information HERE.

Fàilte to the Field lab

    Our laboratory was established in 1994 (Imperial College 1994 - 2004, University of Cambridge 2005 - 2013), and we are presently at the School of Life Sciences, University of Dundee. Our website contains information on research, publications and details of studentships and positions. Overseas applicants are especially encouraged to consider specific funding options and schemes offered by the University, and to get in touch with us. Dundee is the UK's leading young University, best in Scotland and internationally one of the top 200. We are recognised for expertise across a range of disciplines with specific strength in the life sciences and fine arts. Our principle research objectives are the discovery, functional characterisation and validation of novel gene products, drug targets and chemical tools towards neglected diseases to provide therapy, deep insights into protist cell biology and to understand eukaryotic evolution at the molecular level.

Christopher Jackson

IKELOS GmbH

Recent publications

The evolution of organellar coat complexes and organisation of the eukaryotic cell. Rout, M.P., and Field, M.C., (2017) Annual Reviews of Biochemistry 86 637 - 657

Lineage-specific proteins essential for endocytosis in trypanosomes. Manna, P.T., Obado, S., Boehm, C., Gadelha, C., Sali, A., Chait, B.T., Rout, M.P., and Field, M.C., (2017) Journal of Cell Science 130 1379 - 1392

The trypanosome exocyst: A conserved structure revealing a new role in endocytosis. Boehm, C., Obado, S., Manna, P.T., Gadelha, C., O’Reilly, A.J., Munson, M., Chait, B.T., Rout, M.P., and Field, M.C., (2017)  PLoS Pathogens 13 e1006063

Codependence between Trypanosoma nuclear lamina components in nuclear stability and control of gene expression. Maishman, L., Obado, S., Alsford, S., Bart, J.M., Navarro, M., Horn, D., Ratushny, Aitchison, J.D., Chait, B.T., Rout, M.P., and Field, M.C., (2016)  Nucleic Acids Research 44 10554-10570

Ancient eukaryotic origin and evolutionary plasticity of the nuclear lamina. Koreny, L., and Field, M.C., (2016) Genome Biology and Evolution 8 2663 - 2671

Interactome mapping reveals the evolutionary history of the nuclear pore complex. Obado, S., Brillantes, B., Uryu, K., Zhang, W-Z., Ketaren, N.E., Chait, B.T.  Field, M.C., and Rout, M.P. (2016) PLoS Biology 14 e1002365

Modulation of the surface proteome through multiple ubiquitylation pathways in African trypanosomes. Zoltner, M., Leung, K-F., Alsford, S., Horn, D., and Field, M.C., (2015) PLoS Pathogens 11 e1005236

Architecture of a parasite surface: Complex targeting mechanisms revealed through proteomics. Gadelha, C., Zhang, W-Z., Chamberlain, J.W., Chait, B.T., Wickstead, B., and Field, M.C., (2015) Molecular and Cellular Proteomics 14 1911 - 1926

Evolutionary cell biology: Two origins, one objective. Lynch, M., Field, M.C., Goodson, H., Malik, H., Pereira-Leal, J.B., Roos, D., Turkewitz, A., and Sazer, S., (2014) Proceedings of the National Academy of Sciences (USA) 111 16990 - 16994

Molecular palaeontology and unprecedented complexity in the last eukaryotic common ancestor. Koumandou, V.L., Wickstead, B., Ginger, M., van der Geizen, M., Dacks, J.B., and Field, M.C., (2014) Critical Reviews in Biochemistry and Molecular Biology 48 373-396

mfield@mac.com

+44(0)751-550-788